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| Work is Recognized on Cover of Molecular Cancer Research | |
| Kudos to Dr. William Maltese, Dr. Jean Overmeyer and Aparna Kaul for their recent publication in Molecular Cancer Research (Overmeyer, J.H.*, Kaul, A.*, Johnson, E.E., and Maltese, W.A. (2007) Activated Ras triggers death through hyperstimulation of macropinocytosis. Molec. Cancer Res., 6:965-977. *equal contributors). The journal chose their image of a cell undergoing methuosis which was taken with the multiphoton confocal microscope in the UT Advanced Microscopy and Imaging Center on the Health Science Campus. A synopsis of their work can be read in the Sept. 22 issue of UT News. |
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| Congratulations to Dr. Maurice Manning 2008-2009 Distinguished University Professor | |
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Dr. Maurice Manning, Professor of Biochemistry & Cancer Biology, has been appointed one of four new Distinguished University Professorships by the University of Toledo. This exceptional honor recognizes Dr. Manning's distinguished career and contributions to the university as defined by his academic accomplishments, world-wide collaborations and student education. The Academic Honors Committee considered 41 nominations for this year's appointees, based on exemplary teaching, research, scholarship and professional service. |
| New Faculty The Department of Biochemistry & Cancer Biology wishes to welcome Kathryn Eisenmann, Ph.D. Dr. Eisenmann joined the department in August 2008 as an Assistant Professor. Previously she was a Postdoctoral Fellow in the Laboratory of Cell Structure and Signal Integration, Van Andel Research Institute, Grand Rapids, MI. Dr. Eisenmann's research goals are to identify and target critical mechanisms supporting the tumorigenic platform of breast cancer by focusing on the molecular and cellular biology of invasion and metastasis. |
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| Aparna Kaul Receives 2008 Satellite Scholarship Congratulations to Aparna Kaul for receiving the 2008 Satellite's Scholarship award! Aparna was chosen by the Cancer Biology program faculty as the outstanding upper level student in the Cancer Biology track. She is a student in the laboratory of Dr. William Maltese. The Satellites are a group of UTHSC volunteers that have a long tradition of providing support and scholarship to the UTHSC community. Great job, Aparna, and keep up the good work! |
| Vipul Bhrigu Receives Travel Award | |
| Vipul Bhrigu, Cancer Biology program student in the laboratory of Dr. Jim Trempe, received a $1,000 travel award to present his work at the XII Parvovirus Workshop, June 1-5, 2008, Cordoba, Spain. Vipul's abstract was entitled "Replication of AAV in NIH 3T3 cells with mouse adenovirus helper." The workshop covered relevant scientific aspects of the field such as molecular biology and biotechnology, diseases associated to parvovirus infections, and current biomedical applications of the parvoviruses. | |
| Biochemistry & Cancer Biology Graduate in BBC News Health Watch | |
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Biochemistry & Cancer Biology graduate, Dr. Jennifer Timpe, has had her research findings appear on the BBC Health Watch web site, "How Hep C Bypasses Cell Defenses. The potentially-fatal hepatitis C virus evades the body's natural defenses by slipping directly from cell to cell, scientists have found." (http://news.bbc.co.uk/2/hi/health/7075569.stm) Jennifer is currently a postdoctoral fellow at the University of Birmingham, England, and recently presented preliminary research to the International Symposium on Hepatitis C Virus in Glasgow, Scotland. She completed her doctoral studies in the laboratory of Dr. James Trempe, Professor of Biochemistry & Cancer Biology. | |
New Grant Awards
William Maltese, Ph.D. (P.I.), $190,000, National Cancer Institute, "Cell Death in Glioblastoma," 8/1/2007-
5/31/2011.
Ivana de la Serna, Ph.D. (P.I.), $50,000, Ohio Cancer Research Associates, "De-regulation of Chromatin Remodeling by BRAF (V600E) in Melanoma," 7/1/2008-6/30/2010.
Ivana de la Serna, Ph.D. (P.I.), $30,000, American Cancer Society, "SWI/SNF Enzymes in BRAF (V600E) Induced Changes in Melanocyte Gene Expression," 9/1/2008-8/31/2009.
In the News
Dr. James P. Trempe: Provosts announce appointment as Interim Senior Director of Research Administration - UTNEWS, October 21, 2008
Dr. William Maltese, Dr. Jean Overmeyer, and Aparna Kaul: UT research suggests new way of programmed cell death - UTNEWS, September 22, 2008
Dr. Maurice Manning: Provosts announce 2008-2009 Distinguished University Professors - UTNEWS, September 15, 2008
Dr. Kandace Williams: Faculty member to review fellowship applications - UTODAY, March 4, 2008
Dr. David Dignam: New corporation created to take potentially lifesaving invention into marketplace - UTODAY, February 6, 2008
Department spreads holiday cheer to family - UTODAY, December 28, 2007
University of Toledo College of Medicine grad, Jennifer Timpe, quoted by BBC - UTODAY, December 11, 2007
Dr. James Trempe honored at The Inaugural Grand Illusions Saute - Toledo Blade, October 1, 2007
Dr. Kandace Williams named to NIH Study Section - UTODAY, August 21, 2007
UT medical student wins honor society research fellowship and conducts research with Dr. James Trempe and Dr. Roy Collaco - UTODAY, June 20, 2007
Dr. David Dignam member of "UT team's work a potential lifesaver for patients worldwide" - Toledo Blade, May 7, 2007
Student Accomplishments & Announcements
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CONGRATULATIONS Dr. Wu! Yu Wu, has been awarded her Ph.D. in Biomedical Sciences (Cancer Biology program), after successfully defending her dissertation entitled "Identification and functional characterization of adipogenesis-related genes" on October 14, 2008 (mentor: Cynthia Smas, D.Sc.). Dr. Wu has accepted a Postdoctoral Fellowship in the laboratory of Dr. Robert Casero, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, where she will investigate the antineoplastic drug development targeting the polyamine metabolic pathway. |
| CONGRATULATIONS Dr. Zhang! Juan Zhang, has been awarded her Ph.D. in Biomedical Sciences (Cancer Biology program), after successfully defending her Ph.D. dissertation entitled "New mechanisms of androgen receptor signaling" on September 2, 2008. Dr. Zhou was mentored by Dr. Manohar Ratnam, Ph.D. Dr. Zhang has accepted the position of Associate Director of Tumor Pathology at Crown Bioscience Inc., Beijing, P.R. China. | |
| CONGRATULATIONS Shengli Zhou! Shengli Zhou (Cancer Biology program) has successfully defended her Master's dissertation entitled "ZNF451 is Novel Binding Partner of the bHLH Transcription Factor E12" on August 19, 2008. Ms. Zhou was mentored by Dr. Cynthia Smas. | |
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CONGRATULATIONS Dr. Nadkarni! |
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CONGRATULATIONS Dr. Lee! | |
| CONGRATULATIONS Dr. Wang! Zhe Wang has been awarded her Doctor of Philosophy in Biomedical Sciences (Cancer Biology program) as she successfully defended her dissertation entitled "Dissecting the roles of the non-canonical NF-kB signaling in the pathogenesis of lymphoma and autoimmunity" on February 12, 2008. Dr. Wang studied under the guidance of Dr. Han-Fei Ding. She has accepted a Postdoctoral Fellowship in the Dana-Farber Cancer Institute, Harvard University, in the laboratory of Dr. Margaret Shipp, Director of the Lymphoma Program. | |
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Kim, J.Y., Liu, K., Zhou, S., Tillison, K., Wu, Y. and Smas, C.S. (2008) Assessment of fat specific protein 27 (FSP27) in the adipocyte lineage suggests a dual role for FSP27 in adipocyte metabolism and cell death. Am. J. Physiol. Endocrinol. Metab., 294:E654-E667.
Overmeyer, J.H.*, Kaul, A.*, Johnson, E.E., and Maltese, W.A. (2007) Activated Ras triggers death through hyperstimulation of macropinocytosis. Molec. Cancer Res., 6:965-977. (*equal contributors)
Wu, Y., Kim, J.Y., Zhou, S. and Smas, C.M. (2008) Differential screening identifies transcripts with depot-dependent expression in white adipose tissues. BMC Genomics, 9:397.
Wu, Y., and Smas, C.M. (2008) Expression and regulation of transcript for the novel transmembrane protein Tmem182 in the adipocyte and muscle lineage. BMC Research Notes, in press.
Wu, Y., and Smas, C.M. (2008) Wdnm-1 like, a new adipokine with a role in MMP-2 activation. Am. J. Physiol. Endocrinol. Metab., 295:E205-215.
Zhang, J., Wilkinson, J.E., Gonit, M., Keck, R., Selman, S., and Ratnam, M. (2008) Expression and sub-cellular localization of theCCAAT/enhancer binding protein alpha in relation to postnatal development and malignancy of the prostate. Prostate 68:1206-1214.
2007
Bevington, J.M., Needham, P.G., Verrill, K.C., Collaco, R.F., Basrur, V., and Trempe, J.P. (2007) Adeno-Associated Virus Interactions with B23/Nucleophosmin: Identification of Sub-Nucleolar Virion Regions. Virol. 357:102-113.
Blaser, B.*, Gonit, M.*, Qi, H., Shatnawi, A., Guimond, M., Lee, R.J. and Ratnam, M. (2007) Induction of folate receptor type β in a bone marrow engraftment model of acute myelogenous leukemia. Leukemia 21:2233-2235. (*equal contributors)
Cui, H., Hu, B., Li, T., Ma, J., Alam, G., Gunning, W.T., and Ding, H-F. (2007) Bmi-1 is essential for the tumorigenicity of neuroblastoma cells. Am. J. Pathol. 170:1370-1378.
d’Alincourt Salazar, M. and Ratnam, M. (2007) The folate receptor: What does it promise in tissue-targeted therapeutics. Cancer Metastasis Reviews 26:141-152.
Dignam, S., Collaco, R.F., Bieszczad, J., Needham, P., Trempe, J.P., and Dignam, J.D. (2007) Coupled ATP and DNA binding of adeno-associated virus Rep40 helicase. Biochemistry 46:568-576.
Hao, H., d'Alincourt-Salazar, M., Kelley, K.M.M., Shatnawi, A., Mukherjee, S., Shah, Y.M. and Ratnam, M. (2007) Estrogen-Induced and TAFII30-mediated gene repression by direct recruitment of the estrogen receptor and co-repressors to the core promoter and its reversal by tamoxifen. Oncogene 00:1-13, 2007.
Kaul, A.*, Overmeyer, J.H.*, and Maltese, W.A. (2007) Activated Ras induces cytoplasmic vacuolation and non-apoptotic death in glioblastoma cells via novel effector pathways. Cellular Signaling 19:1034-1043. (*equal contributors)
Kim, J.Y., Tillison, K., Zhou, S., Lee, J.H., Smas, C.M. (2007). Differentiation-Dependent expression of Adhfe1 in adipogenesis. Arch. Biochem. Biophys. 464:100-111.
Kim, J.Y., Tillison, K.S., Zhou, S., Wu, Y., and Smas, C.M. (2007). The major facilitator superfamily member Slc37a2 is a novel macrophage-specific gene selectively expressed in obese white adipose tissue. Am. J. Physiol. Endocrinol. Metab., E110-E120.
Kim, J.Y., Wu, Y., and Smas, C.M. (2007) Characterization of ScAP-23, a new cell line from murine subcutaneous adipose tissue, identifies genes for the molecular definition of preadipocytes. Physiol. Genomics 31:328-342.
Keenen, B. and de la Serna, I. (2007) Role of SWI/SNF chromatin remodeling enzymes in melanoma. Pigment Cell Research 20:319.
Lu, Y., Wu., J., Wu, J., Gonit, M., Yang, X., Lee, A., Xiang, G., Li, H., Liu, S., Marcucci, G., Ratnam, M.*, and Lee, R.* (2007) Formulation composition in folate receptor-targeted liposomal doxorubicin delivery to acute myelogenous leukemia cells. Molec. Pharmaceutics, 4:707-712. (*equal contributors)
Salazar, M.D. and Ratnam, M. (2007) The folate receptor: What does it promise in tissue-targeted therapeutics? Cancer Met. Rev. 26:141-152.
Schroering, A., Edelbrock, M.A., Richards, T.J., and Williams, K.J. (2007) The cell cycle and DNA mismatch repair. Exp. Cell Res. 313:292-304.
Shatnawi, A., Tran, T., and Ratnam, M. (2007) R5020 and RU486 act as progesterone receptor agonists to enhance Sp1/Sp4-dependent gene transcription by an indirect mechanism. Mol. Endocrinol. 21:635-650.
Timpe, J., Verrill, K., Ding. H-F., and Trempe, J.P. (2007) Adeno-associated virus induces apoptosis during co-infections with adenovirus. Virology 358:391-401.
Zhang, B., Wang., Z., Li, T., Tsisikov, E.N. and Ding, H-F. (2007) NF-kappa B2 mutation targets TRAF1 to induce lymphomagenesis. Blood (Epub, April 3).
Cui, H., Ma, J., Ding, J., Li, T., Alam, G., and Ding, H-F. (2006) Bmi-1 regulates the differentiation and clonogenic self-renewal of I-type neuroblastoma cells in a concentration-dependent manner. J. Biol. Chem. 45:34696-34704.
Elnakat, H. and Ratnam, M. (2006) Role of folate receptor genes in reproduction and related cancers. Frontiers in Bioscience 11:506-519.
Gruver, A.M., Miller, K.A., Rajesh, C., Smiraldo, P.G., Kaliyaperumal, S., Balder, R., Stiles, K.M., Albala, J.S., and Pittman, D.L. (2006) The ATPase motif in RAD51D is required for resistance to DNA interstrand crosslinking agents and interaction with RAD51C. Mutagenesis 20:433-440.
Johnson, E.E., Overmeyer, J.H., Gunning, W.T. and Maltese, W.A. (2006) Gene silencing reveals a specific function of hVps34phosphatidylinositol 3-kinase in late versus early endosomes. J. Cell Sci. 119: 1219-1232.
Kim, J.Y., Tillison, K., Lee, J.H., Rearick, D.A., and Smas, C.M. (2006). The adipose tissue triglyceride lipase ATGL/PNPLA2 is downregulated by insulin and TNF-alpha in 3T3-L1 adipocytes and is a target for transactivation by PPARgamma. Am. J. Physiol. Endocrinol. Metab. 291:E115-E127.
Koterba, K.L. and Rowan, B.G. (2006) Measuring ligand-dependent and ligand-independent interactions between nuclear receptors and associated proteins using bioluminescence resonance energy transfer (BRET2). Nucl. Recept. Signal. 4:e021.
Needham, P.G., Casper, J., Dignam, J.D., and Trempe, J.P. (2006) Characterization of adeno-associated virus Rep protein-mediated inhibition of transcription of the adenovirus major late promoter in vitro. J. Virology 80:6207-6217.
Timpe, J., Casper, J., Verrill, K., and Trempe, J.P. (2006) Effects of adeno-associated virus on adenovirus replication and gene expression during coinfection. J. Virology 80:7807-7815.
Zeng, X., Overmeyer, J.H., and Maltese, W.A. (2006) Functional specificity of the mammalian Beclin-Vps34 PI 3-Kinase complex in macroautophagy versus endocytosis and lysosomal enzyme trafficking. J. Cell Sci. 119:259-270.
